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Minimal residual disease in solid tumors: an overview

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 649-674 doi: 10.1007/s11684-023-1018-6

Abstract: residual disease (MRD) is termed as the small numbers of remnant tumor cells in a subset of patients with tumorstechniques, and strategies for the detection of cancer, and emphasizes the application of MRD detection in solidtumors, particularly for the guidance of clinical treatment.

Keywords： MRD     solid tumor     CTC     ctDNA    

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Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 333-344 doi: 10.1007/s11705-021-2059-5

Abstract: perspective first discusses the temperature-gradient and the spatially-structured immunological landscape in solidtumors receiving nano-enabled hyperthermia.

Keywords： nano-enabled hyperthermia     immunogenic cell death     heterogeneous immunological landscape     tumor microenvironment    

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Rare tumors: a blue ocean of investigation

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 220-230 doi: 10.1007/s11684-023-0984-z

Abstract: Although rare tumors account for a non-negligible number, the practice of precision medicine and developmentHerein, by reviewing the epidemiological data of Chinese solid tumors and publications defining raretumors in other areas, we proposed a definition of rare tumor in China, including 515 tumor types withLastly, we pinpointed the current recommendation chance for patients with rare tumors to be involved

Keywords： rare tumors     diagnosis flowchart     treatment strategy     clinical trials recommendation    

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they

Keywords： cancer immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: Immunotherapies based on immune checkpoint blockade (ICB) have significantly improved patient outcomes and offered new approaches to cancer therapy over the past decade. To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapy. Blockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers, however, a large subset of refractory patients presents poor responsiveness to ICB therapy; and the underlying mechanism remains elusive. Recently, numerous studies have revealed that metabolic reprogramming of tumor cells restrains immune responses by remodeling the tumor microenvironment (TME) with various products of metabolism, and combination therapies involving metabolic inhibitors and ICIs provide new approaches to cancer therapy. Nevertheless, a systematic summary is lacking regarding the manner by which different targetable metabolic pathways regulate immune checkpoints to overcome ICI resistance. Here, we demonstrate the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting tumor metabolic pathways and immune checkpoints.

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic strategies    

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Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 509-517 doi: 10.1007/s11684-017-0554-3

Abstract: outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumorsNon-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy.

Keywords： malignant germ cell tumors     ovarian sex cord-stromal tumors     fertility-sparing surgery     prognosis     fertility    

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Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 256-264 doi: 10.1007/s11684-009-0052-3

Abstract: More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologic cancer, especially in ovarian cancer. In this article, we systematically review the current targeted therapeutic trials running in clinic. Large, randomized trials have been conducted in the treatment of ovarian cancer, endometrial cancer and cervical cancer by using small molecule, antisense, mutational gene as well as antibodies. Other planned or ongoing trials currentlytargeted at molecular markers which may play important roles in gynecological carcinogenesis andprogression suggest that combination chemotherapy with molecular targeted therapy will ultimately be an importantoption.

Keywords： target therapy     gynecologic malignant tumors     clinical trail     molecular medicine    

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High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Frontiers of Medicine   Pages 907-923 doi: 10.1007/s11684-023-1009-7

Abstract: The characteristic genetic abnormality of neuroendocrine neoplasms (NENs), a heterogeneous group of tumorsWe tested FAK variants in 157 tumor samples collected from Chinese patients with pancreatic tumorsin 34 (75.6%) of 45 pancreatic NENs, 19 (47.5%) of 40 pancreatic solidrepetitive matrix protein 4 (SRRM4) was overexpressed in FAK6/7-positive pancreatic tumorsand breast tumors, which promoted the formation of FAK6/7 in cells.

Keywords： FAK6/7     SRRM4     neuroendocrine neoplasms     pancreas     breast    

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Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 87-94 doi: 10.1007/s11684-008-0016-z

Abstract: The biological behavior of gastrointestinal stromal tumors (GISTs) are highly variable.
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Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 317-321 doi: 10.1007/s11684-012-0203-9

Abstract: order to find out the potential indicators predicting prognosis of malignant gastrointestinal stromal tumorsmedian follow-up of 844 days (52–2 145), we found that as National Institutes of Health suggested, tumorspatients with tumor size≤10 cm and>10 cm were 62.3% and 41.8%, respectively (P = 0.002), Tumorswith mitotic index≤5/50 HPF had a higher 3-year survival rate than tumors with mitotic index>5From the present study, we can conclude that besides tumors size and mitotic index, tumor location and

Keywords： gastrointestinal stromal tumors     surgery     survival    

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Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a comparison with flank approach

Minggen YANG, Xiaokun ZHAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 191-196 doi: 10.1007/s11684-009-0026-5

Abstract: thoracoabdominal incision flank incision for radical nephrectomy in the patients with large renal tumorsThe mean size of tumors in group 1 was significantly smaller than that in group 2 ( < 0.0005).

Keywords： surgery     renal tumors     nephrectomy    

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Plasma spray coating on interconnector toward promoted solid oxide fuel cells and solid oxide electrolysis

Frontiers in Energy doi: 10.1007/s11708-023-0901-9

Abstract: Interconnector is a critical component to construct solid oxide cells (SOCs) stack.

Keywords： interconnector coating     plasma spray     electrochemical performance     Cr diffusion inhibition     solid oxide    

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High-solid anaerobic digestion of sewage sludge: achievements and perspectives

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1364-4

Abstract:

• High-solid anaerobic digestion (HS-AD) of sewage sludge (SS) is overviewed

Keywords： High-solid effect     Anaerobic fermentation     Methane production     Biodegradability     Sludge treatment    

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Review of SO42-/MxOy solid superacid catalysts

Yanni WU, Shijun LIAO

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 330-343 doi: 10.1007/s11705-009-0208-3

Abstract: solid superacid catalysts, play a vital role in more and more fields such as organic synthesis, fineThis review highlights the recent development of solid superacid catalysts based on , including synthesis

Keywords： solid superacid catalyst     synthesis method     characterization     applications    

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Repercussions of COVID-19 pandemic on solid waste generation and management strategies

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1407-5

Abstract:

• Implication of COVID-19 on medical waste and MSW generation is studied.

Keywords： COVID-19     Medical waste     Personal protective equipment     Municipal solid waste     Waste management    

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Title Author Date Type Operation

Minimal residual disease in solid tumors: an overview

Journal Article

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Journal Article

Rare tumors: a blue ocean of investigation

Journal Article

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Journal Article

Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Journal Article

High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Journal Article

Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Journal Article

Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Journal Article

Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a comparison with flank approach

Minggen YANG, Xiaokun ZHAO

Journal Article

Plasma spray coating on interconnector toward promoted solid oxide fuel cells and solid oxide electrolysis

Journal Article

High-solid anaerobic digestion of sewage sludge: achievements and perspectives

Journal Article

Review of SO42-/MxOy solid superacid catalysts

Yanni WU, Shijun LIAO

Journal Article

Repercussions of COVID-19 pandemic on solid waste generation and management strategies

Journal Article